ARG10245

anti-C Peptide antibody [1H8]

anti-C Peptide antibody [1H8] for ELISA,Radioimmunoassay and Human

Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody

Overview

Product Description Mouse Monoclonal antibody [1H8] recognizes C Peptide
Tested Reactivity Hu
Tested Application ELISA, RIA
Specificity No cross-reactivity with human, bovine, porcine and mouse/rat insulin.
Host Mouse
Clonality Monoclonal
Clone 1H8
Isotype IgG1
Target Name C Peptide
Antigen Species Human
Immunogen recombinant C-peptide construction
Conjugation Un-conjugated
Full Name insulin
Alternate Names IDDM; IDDM2; IDDM1; ILPR; MODY10; Insulin; IRDN

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein A affinity purified.
Buffer PBS (pH 7.4) and 0.1% Sodium azide
Preservative 0.1% Sodium azide
Concentration 1.0-2.0 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 3630 Human INS

Swiss-port # P01308 Human Insulin

Gene Symbol INS
Gene Full Name insulin
Background After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. [UniProt]
Research Area Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody

Clone References

At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death.

ICC/IF / Rat

Masuda Y et al.
Am J Transl Res.,  (2013)

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Evidence for an interaction between proinsulin C-peptide and GPR146.

ICC/IF / 

Yosten GL et al.
J Endocrinol.,  (2013)

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