ARG10026

anti-CCL3 antibody [199]

anti-CCL3 antibody [199] for ELISA and Human

Immune System antibody

Overview

Product Description

Mouse Monoclonal antibody [199] recognizes Macrophage Inflammatory Protein 1 alpha

Tested Reactivity Hu
Tested Application ELISA
Specificity Does not show any cross reaction with other human cytokines or growth factors tested such as M-CSF, GM-CSF, IL-7, IL-8, IL-16, IL-1β, bFGF, TGF-β, EGF, TNF-α and EPO.
Host Mouse
Clonality Monoclonal
Clone 199
Isotype IgG2a,k
Target Name CCL3 / MIP1 alpha
Antigen Species Human
Immunogen Purified recombinant human MIP-1α
Conjugation Un-conjugated
Alternate Names MIP-1-alpha; SIS-beta; PAT 464.1; Tonsillar lymphocyte LD78 alpha protein; G0/G1 switch regulatory protein 19-1; Small-inducible cytokine A3; C-C motif chemokine 3; LD78-alpha; 4-69; Macrophage inflammatory protein 1-alpha; MIP1A; SCYA3; G0S19-1; LD78ALPHA

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein G affinity purified
Buffer 0.01M PBS (pH 7.2)
Concentration 1 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 6348 Human CCL3

Swiss-port # P10147 Human C-C motif chemokine 3

Gene Symbol CCL3
Gene Full Name chemokine (C-C motif) ligand 3
Background This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
Function Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). [UniProt]
Resrarch Area Immune System antibody
PTM N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.