ARG10602
anti-CD11c antibody [118/A5]
anti-CD11c antibody [118/A5] for Immunohistochemistry and Human
Overview
| Product Description | Mouse Monoclonal antibody [118/A5] recognizes CD11c |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 118/A5 |
| Target Name | CD11c |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide around the C-terminus of Human CD11C. (ANGQIAPENGTQTPSPPSEK) |
| Conjugation | Un-conjugated |
| Full Name | integrin, alpha X (complement component 3 receptor 4 subunit) |
| Alternate Names | CD antigen CD11c; Leu M5; CD11C; SLEB6; Integrin alpha-X; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11 antigen-like family member C |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Human tonsil |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database links | |
|---|---|
| Gene Symbol | ITGAX |
| Gene Full Name | integrin, alpha X (complement component 3 receptor 4 subunit) |
| Background | This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
| Function | Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [UniProt] |
