anti-CDKN1C / p57 Kip2 antibody

anti-CDKN1C / p57 Kip2 antibody for Western blot and Human

Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody


Product Description Mouse Monoclonal antibody recognizes CDKN1C / p57 Kip2
Tested Reactivity Hu
Tested Application WB
Host Mouse
Clonality Monoclonal
Clone 522CT9.5.1
Isotype IgM
Target Name CDKN1C / p57 Kip2
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 34-64 of Human CDKN1C (NP_000067.1).
Conjugation Un-conjugated
Alternate Names Cyclin-dependent kinase inhibitor p57; BWS; WBS; BWCR; KIP2; Cyclin-dependent kinase inhibitor 1C; p57; p57Kip2

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:16000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HL-60


Purification Affinity purification with immunogen.
Buffer Crude ascites and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 1028 Human CDKN1C

Swiss-port # P49918 Human Cyclin-dependent kinase inhibitor 1C

Gene Symbol CDKN1C
Gene Full Name cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Background This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Function Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [UniProt]
Cellular Localization Nucleus.
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody
Calculated MW 32 kDa

Images (1) Click the Picture to Zoom In

  • ARG54738 anti-CDKN1C / p57 Kip2 antibody WB image

    Western blot: 35 µg of HL-60 cell lysate stained with ARG54738 anti-CDKN1C / p57 Kip2 antibody.