anti-CRP antibody (HRP)
anti-CRP antibody (HRP) for ELISA and Human
Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Immune System antibody; Metabolism antibody
|Product Description||HRP conjugated-Goat Polyclonal antibody recognizes Human CRP|
|Immunogen||Purified CRP from human pleural fluid|
|Full Name||C-reactive protein, pentraxin-related|
|Alternate Names||1-205; PTX1; C-reactive protein|
|Application Note||ELISA: In combination with CRP capture antibody (Clone 63F4, Cat No: ARG10051), this HRP conjugated antibody can be used as tracer in Sandwich ELISA for CRP detection.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|Purification||Protein G affinity purified|
|Buffer||0.01M PBS (pH 7.2) and 50% Glycerol|
|Storage instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Keep the antibody in the dark and keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Background||C-reactive protein (CRP) is an acute phase protein that is comprised of five identical 23kDa subunits. The protein increases rapidly in response to inflammation, trauma and infection, and drops to normal level when the conditions no longer present. CRP plays a role in innate immunity by binding to phosphachlolin on the surface of damaged cells or certain microbes, and activating the C1q complex in complement system. CRP is primarily produced by hepatocytes under the stimulation by inflammatory cytokines including IL-6 and TNF-alpha. Elevated CRP level is implicated with bacterial infection, autoimmune diseases, trauma and post-surgical complications. Study has shown that people with higher CRP baseline have a higher disposition to develop cardiovascular diseases such as heart attack and stroke.|
|Function||Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. [UniProt]|
|Resrarch Area||Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Immune System antibody; Metabolism antibody|