ARG10954

anti-DSG1 / Desmoglein 1 antibody [32-2B]

anti-DSG1 / Desmoglein 1 antibody [32-2B] for Electron microscopy,Immunohistochemistry,ICC/IF,Western blot and Bovine,Human

Overview

Product Description Mouse Monoclonal antibody [32-2B] recognizes DSG1 / Desmoglein 1
Tested Reactivity Hu, Bov
Tested Application EM, ICC/IF, IHC, WB
Host Mouse
Clonality Monoclonal
Clone 32-2B
Isotype IgG2a
Target Name DSG1 / Desmoglein 1
Antigen Species Bovine
Immunogen Bovine desmoglein (desmosomal glycoprotein 1) from nasal epidermis.
Conjugation Un-conjugated
Full Name desmoglein 1
Alternate Names PPKS1; Desmoglein-1; SPPK1; DGI; EPKHIA; CDHF4; DG1; Desmosomal glycoprotein 1; DSG; Cadherin family member 4; Pemphigus foliaceus antigen; EPKHE

Application Instructions

Application Suggestion
Tested Application Dilution
EMAssay-dependent
ICC/IFAssay-dependent
IHCAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified by affinity chromatography.
Buffer PBS and 0.02% Sodium azide.
Preservative 0.02% Sodium azide
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 1828 Human DSG1

GeneID: 281131 Bovine DSG1

Swiss-port # Q02413 Human Desmoglein-1

Swiss-port # Q03763 Bovine Desmoglein-1

Gene Symbol DSG1
Gene Full Name desmoglein 1
Background This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. [UniProt]
Calculated MW 114 kDa