ARG10023

anti-MCSF antibody [116]

anti-MCSF antibody [116] for ELISA and Human

Cell Biology and Cellular Response antibody; Immune System antibody

Overview

Product Description

Mouse Monoclonal antibody [116] recognizes MCSF

Tested Reactivity Hu
Tested Application ELISA
Specificity Does not cross react with BSA or other human cytokines tested such as IL-1β, IL-8, IL-16, EGF, G-CSFR, GM-CSF, MCP-1, MCP-3, TGF-β and TNF-α.
Host Mouse
Clonality Monoclonal
Clone 116
Isotype IgG2b,k
Target Name M-CSF
Antigen Species Human
Immunogen Purified recombinant human M-CSF (rhM-CSF)
Conjugation Un-conjugated
Alternate Names Macrophage colony-stimulating factor 1; CSF-1; Lanimostim; M-CSF; MCSF

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein G affinity purified
Buffer 0.01M PBS (pH 7.2)
Concentration 1 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 1435 Human CSF1

Swiss-port # P09603 Human Macrophage colony-stimulating factor 1

Gene Symbol CSF1
Gene Full Name colony stimulating factor 1 (macrophage)
Background The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Function Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. [UniProt]
Resrarch Area Cell Biology and Cellular Response antibody; Immune System antibody
PTM N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated.