ARG10150

anti-MHC class II antibody [3D6]

anti-MHC class II antibody [3D6] for Flow cytometry,ICC/IF,IHC-Frozen sections,Immunoprecipitation,Western blot and Rat

Immune System antibody

Overview

Product Description Mouse Monoclonal antibody [3D6] recognizes MHC class II
Tested Reactivity Rat
Tested Application FACS, ICC/IF, IHC-Fr, IP, WB
Specificity No cross-reaction with RT-1A,-C,-D rat MHC products
Host Mouse
Clonality Monoclonal
Clone 3D6
Isotype IgG1
Target Name MHC class II
Antigen Species Rat
Immunogen Purified rat MHC class II proteins
Conjugation Un-conjugated
Full Name Cd74 molecule, major histocompatibility complex, class II invariant chain
Alternate Names DHLAG; Ii; CD antigen CD74; II; HLA-DR antigens-associated invariant chain; Ia-GAMMA; Ia antigen-associated invariant chain; HLA class II histocompatibility antigen gamma chain; p33; HLADG

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein A affinity purified.
Buffer PBS (pH 7.4) and 0.1% Sodium azide
Preservative 0.1% Sodium azide
Concentration 1.0-2.0 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 294270 Rat HLA-DPB1

Gene Symbol Cd74
Gene Full Name Cd74 molecule, major histocompatibility complex, class II invariant chain
Background The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Function Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. [UniProt]
Research Area Immune System antibody
PTM N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.