ARG63802

anti-NKG2D / KLRK1 antibody

anti-NKG2D / KLRK1 antibody for Western blot and Human

Immune System antibody

Overview

Product Description Goat Polyclonal antibody recognizes NKG2D / KLRK1
Tested Reactivity Hu
Predict Reactivity Ms, Rat
Tested Application WB
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name NKG2D / KLRK1
Species Human
Immunogen C-KVYSKEDQDLLK
Conjugation Un-conjugated
Alternate Names NKG2-D-activating NK receptor; CD antigen CD314; D6H12S2489E; NK cell receptor D; NKG2-D type II integral membrane protein; NKG2-D; Killer cell lectin-like receptor subfamily K member 1; Nkg2d

Application Instructions

Application Suggestion
Tested Application Dilution
WB0.1 - 0.3 µg/ml
Application Note WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 25 kDa

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 22914 Human KLRK1

Swiss-port # P26718 Human NKG2-D type II integral membrane protein

Background Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
Highlight Related products:
NKG2D antibodies; NKG2D ELISA Kits; Anti-Goat IgG secondary antibodies;
Related news:
Time to fight cancer by NK cells
Research Area Immune System antibody

Images (1) Click the Picture to Zoom In

  • ARG63802 anti-NKG2D / KLRK1 antibody WB image

    Western Blot: human spleen lysate (RIPA buffer, 35 µg total protein per lane) stained with ARG63802 anti-NKG2D / KLRK1 antibody at 0.3 µg/ml dilution.