ARG10164

anti-Papillomavirus 16 E7 antibody [716-281]

anti-Papillomavirus 16 E7 antibody [716-281] for ELISA,Western blot and Human

Microbiology and Infectious Disease antibody

Overview

Product Description Mouse Monoclonal antibody [716-281] recognizes Papillomavirus 16 E7
Tested Reactivity Hu
Tested Application ELISA, WB
Host Mouse
Clonality Monoclonal
Clone 716-281
Isotype IgG2b
Target Name HPV16 E7
Immunogen HPV oncoprotein E7, types 16 & 18
Conjugation Un-conjugated
Full Name transforming protein

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein G affinity purified.
Buffer PBS (pH 7.2) and 0.1% Sodium azide
Preservative 0.1% Sodium azide
Concentration 1.0-2.0 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol E7
Function E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity). [UniProt]
Resrarch Area Microbiology and Infectious Disease antibody

Images (1) Click the Picture to Zoom In

  • ARG10164 anti-Papillomavirus 16 E7 antibody [716-281] WB image

    Western Blot: 15μg/lane recominbinant protein stained with1) ARG10164; 2) MAb [716-D1]; 3) ARG10310; 4) MAb [718-238]

Free antibody sample