ARG10591

anti-TTF1 antibody [G21-G]

anti-TTF1 antibody [G21-G] for IHC-Formalin-fixed paraffin-embedded sections and Human

Overview

Product Description Rabbit Monoclonal antibody [G21-G] recognizes TTF1
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone G21-G
Isotype IgG
Target Name TTF1
Antigen Species Human
Immunogen Synthetic peptide around the N-terminus of Human TTF-1
Conjugation Un-conjugated
Full Name NK2 homeobox 1
Alternate Names TITF1; NKX2.1; BCH; Thyroid nuclear factor 1; BHC; NKX2A; TTF1; TTF-1; Thyroid transcription factor 1; Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; T/EBP; Thyroid-specific enhancer-binding protein; TEBP; NK-2

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA
Preservative 0.05% Sodium azide
Stabilizer 20 mg/ml BSA
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 7080 Human NKX2-1

Swiss-port # P43699 Human Homeobox protein Nkx-2.1

Gene Symbol NKX2-1
Gene Full Name NK2 homeobox 1
Background This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]
Function Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). [UniProt]
PTM Phosphorylated on serine residues by STK3/MST2.

Images (3) Click the Picture to Zoom In

  • ARG10591 anti-TTF1 antibody [G21-G] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human lung adenocarcinoma (4 µm sections) stained with ARG10591 anti-TTF1 antibody [G21-G].

  • ARG10591 anti-TTF1 antibody [G21-G] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human lung adenocarcinoma (4 µm sections) stained with ARG10591 anti-TTF1 antibody [G21-G].

  • ARG10591 anti-TTF1 antibody [G21-G] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human thyroid papillary carcinoma (4 µm sections) stained with ARG10591 anti-TTF1 antibody [G21-G].