A new role of fat – factory of circulating miRNAs

A new role of fat – factory of circulating miRNAs

Adipose tissue is an endocrine organ that secretes a number of proteins, termed adipokines, which play important roles in fat metabolism, feeding behavior, hemostasis, vascular tone, energy balance, and insulin sensitivity. Adipokines raise a great interest as the association of therapeutic possibility for type 2 diabetes, appetite, obesity, and atherosclerosis.

A new role for adipose tissue was reported in Nature recently. Besides releasing adipokines, adipose tissue is also a major source of circulating exosomal miRNAs which are associated with a variety of diseases, including cancer, diabetes, obesity, and cardiovascular disease.

Thomou et al., showed that mice with an adipose-specific knockout of Dicer, the miRNA-processing enzyme, exhibit a decreased levels of circulating miRNAs. The decrease of circulating miRNAs in KO mice can be restored by transplantation of normal adipose tissue. The authors further demonstrated that fat-derived exosomal miRNAs regulate hepatic FGF21 and liver gene expression.

This is the first article reported that adipose tissue is an important source of circulating miRNAs which have far-reaching systemic effects on the regulation of mRNA expression and translation.

offers quality ELISA kits and antibodies to accelerate adipokine study.

Adipokine ELISA Kits (HS: Hyper Sensitive)

Cat. No. Product  Sensitivity 
ARG80131  Human Adiponectin ELISA Kit 80 pg/ml
ARG80110  Human IL6 ELISA Kit 4 pg/ml
ARG80109  Human IL6 (HS) ELISA Kit 0.8 pg/ml
ARG80199  Mouse IL6 ELISA Kit 8 pg/ml
ARG80126  Human Leptin ELISA Kit 8 pg/ml
ARG80941  Human Lipocalin-2 ELISA Kit 15 pg/ml
ARG80128  Human MCP-1 ELISA Kit 8 pg/ml
ARG80212  Mouse MCP-1 ELISA Kit 30 pg/ml
ARG80762  Human PAI-1 ELISA Kit 24 pg/ml
ARG80147  Human Resistin ELISA Kit 8 pg/ml
ARG80120  Human TNF alpha ELISA Kit 8 pg/ml
ARG80206  Mouse TNF alpha ELISA Kit 8 pg/ml

Antibody Dous for ELISA assay

 Adiponectin ELISA Duo (ARG30285)
 Adiponectin antibody [Adn94]
 Detection: Adiponectin antibody [Adn63] 

 RBP4 ELISA Duo (ARG30283)
 RBP4 antibody [RB48]
 Detection: RBP4 antibody [RB42] 

Adipokine Antibodies

Adipophilin antibody [ADPN1-1]

APOE antibody

IGF1 antibody


Leptin antibody

Resistin antibody [1.2_3D7-1D11]

Tissue factor antibody



Human FGF21 ELISA Kit (ARG80158)

Sensitivity: 15 pg/ml
Sample type: Serum, Plasma, Cell culture supernatants
Specificity: No cross-reactivity with FGF-19, FGF-23, FGFR1 (IIIb)/Fc chimera,

                     FGFR1 (IIIc)/Fc chimera, FGFR2 (IIIb)/Fc chimera,
                      FGFR2 (IIIc)/Fc chimera, Klotho