The best solution for PD-1/PD-L1 research

The best solution for PD-1/PD-L1 research


PD-1 is an immune checkpoint protein expressed on the surface of T cells. When PD-1 binds to its ligand PD-L1, an inhibitory signal is transmitted to suppress the cytotoxicity of T cells. Various types of cancer cells overexpress PD-L1 to evade T cell immunity. Further understanding of PD-1/PD-L1 molecular mechanisms is the research focus of cancer immunity.

In addition to membrane-bound forms, soluble PD-1 and PD-L1 (sPD-L1 and sPD-1) have been revealed. The soluble forms increase the complexity of PD-1/PD-L1 signaling. sPD-L1 is produced from tumor cells and can suppress T cell activity. Elevated sPD-L1 level is associated with poorer prognosis. In contrast, sPD-1 is produced via alternative splicing and can improves the anti-tumor immunity by antagonize the inhibitory effect of PD-L1. The levels of sPD-1 and sPD-L1 are potential biomarker for the prediction of prognosis and treatment responses.

arigo offers quality antibodies and ELISA kits to facilitate the understanding of the mechanism and regulation of PD-1/PD-L1 pathway in either human or mouse samples.


 

Best PD-L1 antibody for cancer pathology

PD-L1 antibody [SQab1716] (ARG65862)
* Good for FACS, ICC/IF, IHC-P, IP

 

Best PD-1 and PD-L1 antibodies for studying PD-1/PD-L1 pathway

PD-1 antibody [SQab1732] (ARG66243)
Reactivity: Hu
Application: FACS, ICC/IF, IHC-P, IP

PD-L1 antibody (ARG55930)
Reactivity: Hu, Ms
Application: FACS, ICC/IF, IHC-P, WB

 

Best ELISA kits for detecting sPD-1 and sPD-L1

arigo offers specific and sensitive ELISA kits for detecting sPD-1 and sPD-L1 in samples from patients or mouse animal models.
 

* The most sensitive PD-1 ELISA kits in the market

Human PD-1 ELISA Kit (ARG81360)
Reactivity: 0.44 pg/ml
Sample: Serum, plasma, cell culture supernatant.

Mouse PD-1 ELISA Kit (ARG81342)
Reactivity:
7.86 pg/ml
Sample: Serum, plasma, cell culture supernatant.

 

* The specific PD-L1 ELISA kits

Human PD-L1 ELISA Kit (ARG81929)
Reactivity:
31.25 pg/ml
Sample: Serum, plasma, cell culture supernatant.

Mouse PD-L1 ELISA Kit (ARG81930)
Reactivity:
15.6 pg/ml
Sample: Serum, plasma, cell culture supernatant.

 

* Human PD-L2 ELISA Kit (ARG81580) is also available.