ARG10281
anti-Bacillus anthracis lethal factor antibody [BAL0105]
anti-Bacillus anthracis lethal factor antibody [BAL0105] for ELISA and Bacteria
Microbiology and Infectious Disease antibody
Overview
| Product Description | Mouse Monoclonal antibody [BAL0105] recognizes Bacillus anthracis lethal factor |
|---|---|
| Tested Reactivity | Bacteria |
| Tested Application | ELISA |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BAL0105 |
| Isotype | IgG1 |
| Target Name | Bacillus anthracis lethal factor |
| Antigen Species | Bacillus |
| Immunogen | highly purified Bacillus anthracis lethal factor |
| Conjugation | Un-conjugated |
Application Instructions
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G affinity purified |
| Buffer | PBS (pH 7.4) and 0.1% Sodium azide |
| Preservative | 0.1% Sodium azide |
| Concentration | 1.0-2.0 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | pxo1_107 |
|---|---|
| Gene Full Name | pXO1-107 |
| Function | One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates. [UniProt] |
| Research Area | Microbiology and Infectious Disease antibody |
