ARG10281

anti-Bacillus anthracis lethal factor antibody [BAL0105]

anti-Bacillus anthracis lethal factor antibody [BAL0105] for ELISA and

Microbiology and Infectious Disease antibody

Overview

Product Description Mouse Monoclonal antibody [BAL0105] recognizes Bacillus anthracis lethal factor
Tested Application ELISA
Host Mouse
Clonality Monoclonal
Clone BAL0105
Isotype IgG1
Target Name Bacillus anthracis lethal factor
Antigen Species Bacillus
Immunogen highly purified Bacillus anthracis lethal factor
Conjugation Un-conjugated
Full Name pXO1-107

Application Instructions

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Protein G affinity purified.
Buffer PBS (pH 7.4) and 0.1% Sodium azide
Preservative 0.1% Sodium azide
Concentration 1.0-2.0 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol pxo1_107
Function One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates. [UniProt]
Resrarch Area Microbiology and Infectious Disease antibody
Free antibody sample