Total solution for HMGB1 research

Total solution for HMGB1 research


 

HMGB1 is a multifunctional protein with various roles in different cellular compartments. It is associated with various pathogenesis such as cancers, neurodegenerative disorders, and multiple inflammatory diseases. HMGB1 has attracted the attention of both basic and clinical researchers as HMGB1 is a therapeutic target for a wide range of diseases.  arigo offers a total solution to facilitate the HMGB1-related research.

 

 

 

 

 

Nuclear and cytosolic HMGB1
In the nucleus, HMGB1 acts as a DNA-binding protein for gene transcription, gene regulation and DNA repair. In the cytosol, HMGB1 induces autophagy by interacting with Beclin-1 which results in its dissociation from Bcl2 and the subsequent induction of autophagy.

 

Extracellular HMGB1
In the extracellular compartment, HMGB1 is passively released by necrotic cells and acts as a chemokine and DAMP (Damage-associated molecular pattern) to trigger inflammatory responses. Besides, HMGB1 is also secreted from activated dendritic cells and macrophages and functions as a cytokine, it acts as a ligand for RAGE, TLR-2 and TLR-4 thus activating the signal pathways and the following inflammation responses.

● Stimulation 

HMGB1 protein (ARG70220)
● Active protein
● Low endotoxin
● Works on human and mouse cells

 

● Neutralization

HMGB1 Neutralizing antibody
[SQab20175] (ARG66714)

● Effective in vitro & in vivo neutralization
● Low endotoxin
● Works on human and mouse cells
● Goof for ELISA, FACS, Neut, WB

 

● Detection

HMGB1 antibody [SQab1711] (ARG65863)
● Goof for ELISA, FACS, ICC/IF, IHC-P, WB
● Works on human, mouse, and rat samples

 

● Quantification

The most comprehensive HMGB1 ELISA Kits

● HMGB1 specific. No cross reactivity with HMGB2.
● Suitable for multiple samples from multiple species.
● Easy & Fast procedures.

 

Human HMGB1 ELISA Kit (ARG81185)

Citations:
Di et al., (2019) J Gastroenterol Hepatol. 34(4):728-735.
Riegger et al., (2019) Cell Death Dis. 10(10):683.
Kang et al., (2020) Toxicol Lett. S0378-4274(20)30146-6.
Chen et al., (2020) J Hepatobiliary Pancreat Sci. 27(8):522-530.
Volchuk et al., (2020) Nat Commun. 11(1):4561.
Wang et al., (2020) Oncogenesis. 9(9):82.

 


Mouse/Rat HMGB1 ELISA Kit (ARG81310)

Citations:
Takahashi et al., (2019) Oncotarget. 10(6):633-646.
He et al., (2019) J Cell Physiol. 234(10):17314-17325.
Ji et al., (2019) Aging. 11(13):4338-4353.
Song et al., (2019) Nat Commun. 10(1):3745.
Liu et al., (2019) Oxid Med Cell Longev. 2019:1703709.
Wang et al., (2020) Oncogenesis. 9(9):82.
Jiang et al., (2020) Exp Brain Res. 238(12):2897-2908.
Kim et al., (2020) Vaccines (Basel). 8(4):699.

 

Serum HMGB1 ELISA Kit (ARG81351)

Citations:
Akasaka et al., (2019) Int J Mol Sci. 20(21):5462
Wen et al., (2020) FASEB 34(3):4384-4402.
Wei et al., (2020) Neuroscience. 437:23-33.
Matsumoto et al., (2020) Pancreas. 49(4):503-508.