Epithelial mesenchymal transition (EMT)

Epithelial mesenchymal transition (EMT)


The epithelial-mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell-cell adhesion, gain migratory and invasive properties to become mesenchymal stem cells. EMT has been shown to occur in wound healing, organ fibrosis and in the initiation of metastasis for cancer progression.



TOP 3  EMT must-haves

Vimentin Antibody

A: MCF-7 (Negative Control), B: MDAMB231 (Metastatic Breast Cancer)

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Vimentin is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-to-mesenchymal transition (EMT) during both normal development and metastatic progression.

Reactivity: Human, Monkey
Application: ICC/IF, IP, WB



SNAIL Antibody

A: PC3 (Metastatic Prostate Cancer), B: 293T (Low expression)

SNAIL protein is involved in the induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration.

Reactivity: Human, Mouse
Application: WB



N-Cadherin Antibody

A: Mouse Brain, B: Rat Brain, C: Hela (Negative Control)

N-cadherin, also known as CDH2, is a transmembrane protein expressed in multiple tissues and functions to mediate cell-cell adhesion.N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration.

Reactivity: Human, Mouse, Bovine, Chicken
Application: WB, IHC