Epithelial-Mesenchymal Transition (EMT)

Epithelial-Mesenchymal Transition (EMT)

 

Epithelial-mesenchymal transition (EMT) is a process by which polarized epithelial cells are transformed into mesenchymal cells and show reduced cell adhesion, increased motility and invasive properties. EMT is classified into 3 types: type 1 is associated with embryonic development of many tissues and organs, type 2 is associated with repair processes including wound healing, tissue regeneration, and organ fibrosis, and type 3 is associated with cancer progression and metastasis.

arigo offers excellent EMT marker antibodies for studying the transition and transcription regulation by transcription factors.
 

Loss of epithelial markers Transcriptional shift Gain of mesenchymal markers
 

E-Cadherin
Claudins
Cytokeratins

Desmoglein
Desmocollin
Occludin

Snail
Slug
Twist

ZEB1/2
FoxC2
LEF-1

Vimentin
N-Cadherin
Fibronectin

Vitronectin
α-SMA
S100A

 

 

Epithelial markers
E-Cadherin antibody
(ARG55914)
ZO-1 antibody
(ARG55738)
 
 
 
Cat. No. Product Clonality Reactivity Application
ARG65402 E-Cadherin antibody [67A4] Mouse mAb Hu FACS, ICC/IF, IHC-Fr, IP, WB
ARG65689 E-Cadherin antibody Rabbit pAb Hu, Ms IHC-P, WB
ARG10954 Desmoglein 1 antibody [32-2B] Mouse mAb Hu, Bo EM, IHC, ICC/IF, WB
ARG70009 Desmocollin antibody Rabbit pAb Hu WB, IHC-P, FACS
ARG57245 JAM-A antibody [RM275] Rabbit mAb Hu IHC-P, WB
ARG53386 Occludin antibody Rabbit pAb Hu, Ms IHC-P, WB
ARG57552 ZO-1 antibody Rabbit pAb Hu, Ms, Rat IHC-P, WB
ARG55738 ZO-1 antibody Goat pAb Hu, Ms, Rat,
Dog, Mk
ICC/IF, WB
 
Mesenchymal markers
Vimentin antibody [SQab1859]
(ARG66302)
N-Cadherin antibody
(ARG54603)
Fibronectin antibody
(ARG66162)
 
α-SMA antibody (ARG66246) S100A4 antibody (ARG55904)  
 
 
Cat. No. Product Clonality Reactivity Application
ARG66302 Vimentin antibody [SQab1859] Mouse mAb

Hu, Ms, Rat, Ch,
Dog, Gt, Hm, Mk,
Pig, X, Zfsh

FACS, ICC/IF, IHC-P,
IHC-Fr, WB
ARG57642 Vimentin antibody Rabbit pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
ARG52468 Vimentin antibody Chicken pAb Hu, Ms, Rat, Bo ICC/IF, WB
ARG22587 N-Cadherin antibody [13A9] Mouse mAb Hu, Rat ICC/IF, IHC-P, IHC-Fr,
IP, WB
ARG54603 N-Cadherin antibody Rabbit pAb Hu, Ms, Rat, Bo, Ch IHC, WB
ARG56127 Fibronectin antibody [FN12-8] Mouse mAb Hu, Bo IHC-P, IHC-Fr, Inhib, WB
ARG65892 Fibronectin antibody Rabbit pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
ARG52485 ​α-SMA antibody [1A4] Mouse mAb Hu, Ms, Rat,
Pig, Rb, Sh
ELISA, ICC/IF, IHC-P,
IHC-Fr, WB
ARG66246 α-SMA antibody [SQab1735] Rabbit pAb Hu, Ms, Rat FACS, IHC-P, WB
ARG63621 α-SMA antibody Goat pAb Hu, Ms, Rat, Pig ICC/IF, IHC-P, WB
ARG55904 S100A4 antibody Mouse mAb Hu IP, WB
ARG55205 S100A4 antibody Rabbit pAb Hu, Ms, Rat IHC-P, WB
ARG64101 S100A4 antibody Goat pAb Hu IHC-P, WB
ARG54601 Vitronectin antibody [VN58-1] Mouse mAb Hu ELISA, IHC
 
Transcription factors for EMT
Snail antibody (ARG64061) Slug antibody (ARG57696) Bmi-1 antibody (ARG55885)
 
Cat. No. Product Clonality Reactivity Application
ARG54986 Snail antibody Mouse mAb Hu IHC-P, WB
ARG56427 Snail antibody Rabbit pAb Hu, Ms, Rat IHC-P, WB
ARG64061 Snail antibody Goat pAb Hu, Ms IHC, WB
ARG55242 Slug antibody Rabbit pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
ARG57641 Twist1 antibody Rabbit pAb Hu, Ms, Rat ICC/IF, WB
ARG57524 ZEB1 antibody Mouse mAb Hu FACS, IHC-P, WB
ARG64856 ZEB1 antibody Goat pAb Hu, Ms WB
ARG55885 Bmi-1 antibody Rabbit pAb Hu, Ms ICC/IF, WB
ARG63332 FOXC2 antibody Goat pAb Hu IHC-P, WB
ARG64029 LEF1 antibody Goat pAb Hu, Ms, Rat WB
ARG64126 TCF3 antibody Goat pAb Hu IHC-P, WB