ARG23959

anti-IL17 / IL17A antibody [SQab19143] (low endotoxin)

anti-IL17 / IL17A antibody [SQab19143] (low endotoxin) for Neutralizing and Human,Rhesus Monkey,Macaque,Marmoset

Overview

Product Description Low endotoxin Mouse Monoclonal antibody [SQab19143] recognizes IL17 / IL17A
Tested Reactivity Hu, Macaq, Marmoset, R. Mk
Tested Application Neut
Host Mouse
Clonality Monoclonal
Clone SQab19143
Isotype IgG1
Target Name IL17 / IL17A
Antigen Species Human
Immunogen Recombinant Human IL17A protein.
Conjugation Un-conjugated
Alternate Names IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8

Application Instructions

Application Suggestion
Tested Application Dilution
NeutAssay-dependent
Application Note Neutralization dose 50 (ND50): The antibody neutralized the effect of IL17A at a ND50 value of 0.01 - 0.03 µg/ml when 10 ng/ml of recombinant Human IL17A was present.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein G.
Purification Note 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg.
Buffer PBS
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 3605 Human IL17A

Swiss-port # Q16552 Human Interleukin-17A

Gene Symbol IL17A
Gene Full Name interleukin 17A
Background The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Function Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt]
Cellular Localization Secreted. [UniProt]
Highlight Related products:
IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Anti-Mouse IgG secondary antibodies;
Related news:
HMGB1, a biomarker and therapeutic target in COVID-19
Calculated MW 18 kDa
PTM Found both in glycosylated and nonglycosylated forms. [UniProt]

Images (1) Click the Picture to Zoom In

  • ARG23959 anti-IL17 / IL17A antibody [SQab19143] (low endotoxin) Neutralization image

    Neutralization: ARG23959 anti-IL17 / IL17A antibody [SQab19143] (low endotoxin) neutralized IL6 production induced by human recombinant IL17A protein.