ARG46147
anti-LMAN1 antibody
anti-LMAN1 antibody for Western blot and Human,Mouse
Overview
| Product Description | Mouse Monoclonal antibody recognizes LMAN1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | LMAN1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide near the carboxy terminus of human LMAN1. |
| Conjugation | Un-conjugated |
| Alternate Names | LMAN1; F5F8D; ERGIC-53; ER-Golgi intermediate compartment 53 kDa protein; FMFD1; Protein ERGIC-53; MR60; gp58; ERGIC53; Lectin mannose-binding 1; Intracellular mannose-specific lectin MR60; MCFD1; Gp58 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Purification | Purification with Protein A |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | LMAN1 |
| Gene Full Name | lectin, mannose-binding, 1 |
| Background | The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015] |
| Function | Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. [UniProt] |
| Cellular Localization | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 56 kDa |
| PTM | The N-terminal may be partly blocked. [UniProt] |
