ARG56879

anti-MICB antibody

anti-MICB antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

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Overview

Product Description Rabbit Polyclonal antibody recognizes MICB
Tested Reactivity Hu
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name MICB
Species Human
Immunogen Recombinant protein of Human MICB.
Conjugation Un-conjugated
Full Name MHC class I polypeptide-related sequence B
Alternate Names MHC class I polypeptide-related sequence B; MIC-B; PERB11.2

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-PAssay-dependent
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control NCI-H460
Calculated MW 43 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 4277 Human MICB

Swiss-port # Q29980 Human MHC class I polypeptide-related sequence B

Gene Symbol MICB
Gene Full Name MHC class I polypeptide-related sequence B
Background This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Function Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. [UniProt]
Highlight Related products:
MICB antibodies; MICB ELISA Kits; Anti-Rabbit IgG secondary antibodies;
Related news:
Time to fight cancer by NK cells
PTM Proteolytically cleaved and released from the cell surface of tumor cells.

Images (1) Click the Picture to Zoom In

  • ARG56879 anti-MICB antibody WB image

    Western blot: NCI-H460 cell lysate stained with ARG56879 anti-MICB antibody.

Specific References

High MICB expression as a biomarker for good prognosis of colorectal cancer.

IHC-P / Human

Feng Qingyang et al.
J Cancer Res Clin Oncol.,  (2020)

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