ARG53688

anti-TGF beta 3 antibody

anti-TGF beta 3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat

Cancer antibody; Developmental Biology antibody; Signaling Transduction antibody
publication_link Publication1

Overview

Product Description Rabbit Polyclonal antibody recognizes TGF beta 3
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, IP, WB
Specificity The antibody majorly reacts to TGF beta 3, but also reacts to TGF beta 2 with weak signals.
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TGF beta 3
Antigen Species Human
Immunogen Synthetic peptide derived from C-terminus of the precursor form of human TGF beta 3 (CYLRSADTTHSTVLGLYNTLNPEASAS).
Conjugation Un-conjugated
Alternate Names TGF-beta3; RNHF; LAP; ARVD; ARVD1; Transforming growth factor beta-3; TGF-beta-3

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100
IPAssay-Dependent
WBAssay-dependent
Application Note IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Incubation Time: 10 min at RT.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Placenta

Properties

Form Liquid
Purification Immunogen affinity purified
Buffer PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide
Preservative < 0.1% Sodium azide
Stabilizer 1% BSA
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 25717 Rat TGFB3

GeneID: 7043 Human TGFB3

Swiss-port # P10600 Human Transforming growth factor beta-3

Swiss-port # Q07258 Rat Transforming growth factor beta-3

Gene Symbol TGFB3
Gene Full Name transforming growth factor, beta 3
Background This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]
Function Involved in embryogenesis and cell differentiation. [UniProt]
Cellular Localization Cytoplasm
Research Area Cancer antibody; Developmental Biology antibody; Signaling Transduction antibody
Calculated MW 12.5 kDa (reduced); 25 kDa (non-reduced)
PTM The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive.

Images (1) Click the Picture to Zoom In

  • ARG53688 anti-Transforming Growth Factor beta 3 antibody IHC-P image

    Immunohistochemistry: Human Placenta stained with ARG53688 anti-TGF beta 3 antibody.

Specific References

Pathobiological Study of Leiomyomatoid Angiomatous Neuroendocrine Tumor (LANT)-Like Tumor in the Myometrium.

IHC-P / Human

Hayashi Takuma et al.
Clinics Oncology.,  (2019)

publication_link

 

hr_line