SM5-1, a promising immunotherapy for Hepatocellular Carcinoma (HCC)

SM5-1, a promising immunotherapy for Hepatocellular Carcinoma (HCC)


Hepatocellular carcinoma (HCC), a type of liver cancer, has become one of the leading causes of cancer-related deaths, especially in Asia. Despite traditional treatments such as surgery, chemotherapy, and radiation, in recent years, tumor-targeted therapy and immunotherapy have been widely studied and considered as new and promising treatments for HCC. SM5-1 is a monoclonal antibody that can inhibit tumor cell growth and induce apoptosis. SM5-1 binds specifically to P230, a membrane protein overexpressed in several types of cancer including HCC, melanoma and breast cancer, therefore chosen as a candidate target for diagnosis and treatment.

In a research published in Biomaterials, scientists developed SM5-1 conjugated gold nanoparticles (Au-SM5-1 NPs) that further enhance the immunotherapy for HCC. Au NPs help extending the retention time of SM5-1 in tumor and inhibiting the rate of cancer cell proliferation. In addition, down regulation of DUOX2 and NOX1 upon Au-SM5-1 NPs binding affects expression level of oxidase and interferes the dynamic balance of reactive oxygen species enzyme system, finally resulting in apoptosis. P21, a negative regulatory factor of cell cycle, is also up-regulated by Au-SM5-1 NPs which leads to cell cycle arrest at G1/S or G2/M phase. Finally, because of the longer retention time in tumor, accumulated Au-SM5-1 NPs subsequently inhibits angiogenesis which often cause uncontrollable tumor growth and metastasis.

Studies of antibody conjugated nanoparticle provide a new approach for target therapy of different kinds of cancer. arigo is proud to provide high quality antibodies for the study of cancer and tumor metastasis.

Tumor Proliferation Marker

ARG53222  Ki67 antibody

Angiogenesis Marker

ARG52748  CD31 antibody

Tumor Metastasis Marker

ARG55540  Vimentin antibody


ARG54910​  SNAIL antibody

Apoptosis Marker

ARG20041​  Active PARP antibody

A: HeLa (DMSO)
B: HeLa (Staurosporine 4 hours)


ARG54155​  Active Caspase 9 antibody

A: HeLa (DMSO)
B: HeLa (Staurosporine 4 hours)

Ma X., Hui H., Jin Y., Dong D., Liang X., Yang X., Tan K., Dai Z., Cheng Z. and Tian J. (2016) Biomaterials 87:46-56