Activation of IL-1 beta and IL-18 by Canonical Inflammasome Pathway

Activation of IL-1 beta and IL-18 by Canonical Inflammasome Pathway

Inflammasomes are complexes formed by several proteins as a platform to recruit, cleave or activate inflammatory caspases. When an injury or infection occurs, inflammasomes can be directly or indirectly activated by a broad panels of danger-associated molecular patterns (DAMPs). The downstream cascade is initiated by the activation of Caspase-1 which in turns cleave pro-IL-1b or pro-IL-18 into mature IL-1b and IL-18. When these cytokines are secreted, they are able to trigger inflammation process through T-cell or B-cell activations by further induction of secondary pro-inflammatory cytokines. A better understanding of the complexity in inflammasomes shed some light on the fine-tuning of mammalian innate immunity, as well as the onset of autoimmune diseases.

arigo is proud to present our best-selling IL-1 beta (ARG80196, ARG80101, ARG80235) and IL-18 (ARG80138, ARG80946) ELISA kits for human, mouse and rat.


  IL-1b ELISA Kit IL-18 ELISA Kit
ARG80101 ARG80196 ARG80235 ARG80138 ARG80946
Human Mouse Rat Human Mouse
 Sensitivity 4 pg/ml 8 pg/ml 30 pg/ml 8 pg/ml 62 pg/ml
7.8-500 pg/ml 15.6-1000 pg/ml 62.5-4000 pg/ml 15.6-1000 pg/ml 125 - 8000 pg/ml
 Sample Type Serum, Plasma, Cell culture supernatants

Why choose arigo’s ELISA kits?

Because arigo guarantees to provide reliable ELISA kits to give you the most consistent results.

Quality Antibody Pairs:

arigo carefully selects antibody pairs that give the best performance in ELISA assay.

Excellent Reproducibility:

We ensure that the CV values for intra- and inter-assay precision to fall below 10%.

Highly Specific:

Linearity assays are performed to ensure minimal interference in various samples.

Minimal Cross-Reactivity:

Substances of  similar structure are tested for cross-reactivity to ensure specificity of assays.

PhD Technical Support:

Our phD technical support team is always here to help you solve your ELISA troubles.


Henao-Mejia et al. (2012). Nature Immunology 13, 321-324
So et al. (2013). Nature Reviews Rheumatology 9, 391-399