Has “Obesity gene” been found?

Has “Obesity gene” been found?


Obesity is linked to increase risk of diabetes, heart disease, and some forms of cancer. More than one-third of adults in the United States are obese, and that number continues to increase every year. More importantly, the number of obese children is also in the rise. Scientists have been putting a lot of effort to identify genes that might regulate the production and growth of fat cells. Specifically, 14-3-3 zeta has recently been demonstrated to be an important cause factor of obesity.

This gene, which encodes a protein called 14-3-3 zeta, is found in every cell of the body. When this gene is conditionally ablated in mice, a 50% reduction in the amount of unhealthy “white fat”, which is associated to obesity, was observed. On the other hands, mice with overexpression of 14-3-3 zeta were noticeably bigger and rounder. Generally, fat can be gained either through the multiplication of their fat cells or the expansion of individual fat cell. 14-3-3 zeta proteins affect both mechanisms by playing a role in the growth and cell cycle of these cells. This discovery pointed to a possible drug therapy, as described by the article published in the recently edition of Nature Communications.
(NATURE COMMUNICATIONS 6:7671; DOI: 10.1038/ncomms8671)

There are 7 members in the family of 14-3-3 proteins, and each of them plays different role involving several signaling mechanisms. arigo provides 14-3-3 Family Antibody Panel (ARG30116) to investigate the individual functions and roles of each member. There are two types of fat cells in our body: “white fat” which is unhealthy and linked to obesity, heart diseases and diabetes; and “brown fat” which is healthy fat that prevent us from having complications related to obesity. White / Brown Fat Cell Marker Antibody Duo (ARG30137) includes Adiponectin (white fat cell marker) and UCP1 (brown fat cell marker) antibodies to distinguish these two cell types in our body. To further understand the mechanism of 14-3-3 zeta , arigo offers high sensitive Leptin ELISA Kit (ARG80126) for elucidating the relationship between 14-3-3 zeta and leptin in obesity.


Antibody Duo


White / Brown Fat Cell Marker Antibody Duo (ARG30137)



Adiponectin Antibody



UCP1 Antibody



Antibody Panel


14-3-3 Family Antibody Panel (ARG30116)


14-3-3 tau Antibody



14-3-3 beta Antibody



14-3-3 sigma Antibody



14-3-3 zeta Antibody






Leptin ELISA Kit (ARG80126)



Leptin ELISA Kit