ARG30252

Dengue virus NS1 ELISA Antibody Duo

Microbiology and Infectious Disease antibody

Component

Cat No Component Name Host clonality Reactivity Application Package
ARG65661 anti-Dengue virus NS1 antibody [SQab1502] Mouse mAb DEN ELISA, ICC/IF 50 μg
ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) Mouse mAb DEN ELISA, ICC/IF 50 μg

Overview

Product Description Dengue virus NS1 protein is a nonstructural protein which could be secreted and have been developed as diagnostic biomarker for early detection. There are several forms of NS1 including monomer, dimer, and hexamer during infection. Dimeric NS1 can be anchored to cell membranes with glycosyl-phosphatidylinositol (GPI). Hexameric NS1 can be secreted and detected in patients' blood samples (up to 50 μg/mL) or infected cell supernatants (various from ng/mL to μg/mL depend on serotypes and strains). Studies have shown that NS1 could interfere complement activity and prothrombin activation. In addition, NS1 could elicit antibodies which cross-react with host antigens including coagulation factors and molecules expressed in endothelial cells and platelets through molecular mimic.
arigo Dengue virus NS1 ELISA Duo could be used to recognize monomer, dimer and hexamer of DENV1/2/3/4 NS1 protein

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Exploring Antiviral Immune Response
Specificity Monomer and hexamer of DENV1/2/3/4 NS1 protein
Target Name Dengue virus NS1
Alternate Names Dengue virus NS1 ELISA antibody; Dengue virus nonstructural protein 1 ELISA antibody; Dengue virus NS1 antibody; Biotin-conjugated Dengue virus NS1 antibody

Properties

Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol DENV_gp1
Gene Full Name Dengue virus nonstructural protein 1 (NS1) ELISA Antibody Duo
Background Dengue virus NS1 protein is a nonstructural protein which could be secreted and have been developed as diagnostic biomarker for early detection. There are several forms of NS1 including monomer, dimer, and hexamer during infection. Dimeric NS1 can be anchored to cell membranes with glycosyl-phosphatidylinositol (GPI). Hexameric NS1 can be secreted and detected in patients' blood samples (up to 50 μg/mL) or infected cell supernatants (various from ng/mL to μg/mL depend on serotypes and strains). Studies have shown that NS1 could interfere complement activity and prothrombin activation. In addition, NS1 could elicit antibodies which cross-react with host antigens including coagulation factors and molecules expressed in endothelial cells and platelets through molecular mimic.
Function Dengue virus (DENV) non-structural protein 1 (NS1) is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome. [Uniprot]
Highlight Related products:
Dengue Virus antibodies; Dengue Virus ELISA Kits; Dengue Virus Duos / Panels;
Research Area Microbiology and Infectious Disease antibody

Images (2) Click the Picture to Zoom In

  • ARG65661 anti-Dengue virus NS1 antibody [SQab1502] & ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) ELISA image

    ELISA: E. coli expressed recombinant Dengue virus type 1-4 NS1 protein (major in monomer) detected by ARG65661 anti-Dengue virus NS1 antibody [SQab1502] as capture antibody (2.5 μg/ml), and ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) (0.5 μg/ml) as detection antibody, followed by incubation with streptavidin-HRP.

  • ARG65661 anti-Dengue virus NS1 antibody [SQab1502] & ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) ELISA image

    ELISA: 293 cells expressed dengue virus type 2 NS1 protein (major in hexamer) detected by ARG65661 anti-Dengue virus NS1 antibody [SQab1502] as capture antibody (2.5 μg/ml), and ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) (0.5 μg/ml) as detection antibody, followed by incubation with streptavidin-HRP.