Ferroptosis Marker and Regulator antibody panels

Ferroptosis is an iron-dependent, regulated form of non-apoptotic cell death driven by the accumulation of lipid peroxides. It shares key features with oxytosis, including depletion of glutathione (GSH), reduced GPX4 activity, and increased lipid peroxidation. Ferroptosis is implicated in diverse physiological and pathological processes, including cancer cell death, neurodegenerative diseases, and ischemia-reperfusion injury. Targeting ferroptosis represents a promising therapeutic strategy for cancer and neurodegenerative disorders.

Ferroptosis is driven by iron overload, lipid peroxidation, and failure of GSH/GPX4 antioxidant system. Lipid metabolism contributes by supplying polyunsaturated fatty acids (PUFAs), which are incorporated into membrane phospholipids and serve as substrates for peroxidation. Iron metabolism increases intracellular iron levels, facilitating Fenton reactions that generate ROS and promote lipid peroxidation. System Xc⁻-GSH-GPX4 axis functions as the primary antioxidant defense, preventing lipid peroxidation and protecting against ferroptosis. Collectively, the core regulatory mechanisms of ferroptosis involve iron metabolism, lipid metabolism, and System Xc⁻-GSH-GPX4 pathway.

arigo provides Ferroptosis/Oxytosis (ARG30337) and Ferroptosis Regulator (ARG30357) antibody panels to facilitate the detection of ferroptosis and support advanced research into the molecular regulation of ferroptosis.

Ferroptosis/Oxytosis Antibody Panel (ARG30337)

Ideal for studying ferroptosis in cancer cells and oxytosis in neuronal cells

* Includes the key molecules GPX4 and xCT/SLC7A11 antibodies
* Includes lipid peroxidation marker 4-HNE antibody
* Works on human, mouse, and rat samples

Ferroptosis Regulator Antibody Panel (ARG30357)

Ideal for investigating regulation pathways of feroptosis

* Includes antioxidant defense regulator GPX4 antibody
* Includes lipid metabolism regulator ACSL4 antibody
* Includes iron storage regulator FTH1 antibody
* Includes iron uptake regulator TfR1 antibody
* Works on human, mouse, and rat samples