ARG70867
Human Bcr recombinant protein (His-tagged, C-ter)
Human Bcr recombinant protein (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | E. coli expressed, His-tagged (C-ter) Bcr recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | Bcr |
| Species | Human |
| A.A. Sequence | Ile161 - Leu260 |
| Expression System | E. coli |
| Alternate Names | ALL; CML; Renal carcinoma antigen NY-REN-26; D22S11; PHL; D22S662; BCR1; EC 2.7.11.1; Breakpoint cluster region protein |
Properties
| Form | Powder |
|---|---|
| Buffer | PBS |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration approximately 1 mg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C, protected from light and moisture, for up to 12 months. After reconstitution , aliquot and store at 2 to 8°C for up to 2 days, or at -20°C or -80°C for up to 3 months Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
Bioinformation
| Gene Symbol | BCR |
|---|---|
| Gene Full Name | breakpoint cluster region |
| Background | GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. |
| Function | GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. [UniProt] |
| PTM | Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2. |
