ARG70625
Human CCL21 / Exodus 2 recombinant protein (Active)
Human CCL21 / Exodus 2 recombinant protein (Active) for SDS-PAGE
Overview
| Product Description | E. coli expressed, Active Human CCL21 / Exodus 2 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CCL21 / Exodus 2 |
| Species | Human |
| A.A. Sequence | Ser24 - Pro134 |
| Expression System | E. coli |
| Activity | Active |
| Activity Note | Determined by a chemotaxis bioassay using human lymphocytes is in a concentration range of 10 - 100 ng/ml. |
| Alternate Names | CCL21; C-C Motif Chemokine Ligand 21; 6Ckine; SLC; SCYA21; TCA4; CKb9; ECL; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 21; Efficient Chemoattractant For Lymphocytes; Secondary Lymphoid Tissue Chemokine; Chemokine (C-C Motif) Ligand 21; Beta Chemokine Exodus-2; C-C Motif Chemokine 21; Exodus-2; Secondary Lymphoid-Tissue Chemokine; Small-Inducible Cytokine A21; Beta-Chemokine Exodus-2 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 97% (by SDS-PAGE or HPLC). |
| Buffer | 20 mM PB, with 150 mM NaCl (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CCL21 |
|---|---|
| Gene Full Name | C-C Motif Chemokine Ligand 21 |
| Background | This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014] |
| Function | Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| PTM | Disulfide bond. [UniProt] |
