ARG70921
Human CD3D recombinant protein (His-tagged, C-ter)
Human CD3D recombinant protein (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | HEK293 expressed, His-tagged (C-ter) CD3D recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD3D |
| Species | Human |
| A.A. Sequence | Val11 - Asp100 |
| Expression System | HEK293 |
| Alternate Names | CD3D; CD3 Delta Subunit Of T-Cell Receptor Complex; T-Cell Surface Glycoprotein CD3 Delta Chain; CD3-DELTA; CD3DELTA; T3D; CD3d Antigen, Delta Polypeptide (TiT3 Complex); CD3d Molecule, Delta (CD3-TCR Complex); T-Cell Receptor T3 Delta Chain; CD3 Antigen, Delta Subunit; OKT3, Delta Chain; CD3d Molecule; CD3d Antigen; CD3 Delta; IMD19 |
Properties
| Form | Powder |
|---|---|
| Buffer | PBS |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration approximately 1 mg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C, protected from light and moisture, for up to 12 months. After reconstitution , aliquot and store at 2 to 8°C for up to 2 days, or at -20°C or -80°C for up to 3 months Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
Bioinformation
| Gene Symbol | CD3D |
|---|---|
| Gene Full Name | CD3 Delta Subunit Of T-Cell Receptor Complex |
| Background | The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. |
| Function | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. |
| Cellular Localization | Cell membrane, Membrane |
| PTM | Disulfide bond, Glycoprotein, Phosphoprotein |
