ARG70822
Human CD70 recombinant protein (Active) (His-tagged, C-ter)
Human CD70 recombinant protein (Active) (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged (C-ter) Active Human CD70 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD70 |
| Species | Human |
| A.A. Sequence | Gln39 - Pro193 |
| Expression System | CHO |
| Activity | Active |
| Activity Note | Determinedd by its ability to bind human CD27 in functional ELISA. Immobilized Recombinant human CD27 Protein at 2 μg/mL (100 μL/well) can bind Recombinant Human CD70 Protein. |
| Alternate Names | CD70; CD70 Molecule; CD27-L; CD27L; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; Tumor Necrosis Factor Ligand Superfamily Member 7; Tumor Necrosis Factor (Ligand) Superfamily, Member 7; Tumor Necrosis Factor Ligand 8A; Surface Antigen CD70; Ki-24 Antigen; TNLG8A; LPFS3 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 85% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CD70 |
|---|---|
| Gene Full Name | CD70 Molecule |
| Background | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] |
| Function | The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. [UniProt] |
| Cellular Localization | Cell membrane, Membrane. [UniProt] |
| PTM | Disulfide bond, Glycoprotein. [UniProt] |
