ARG70932
Human CHD4 recombinant protein (His-tagged, C-ter)
Human CHD4 recombinant protein (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | E. coli expressed, His-tagged (C-ter) CHD4 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CHD4 |
| Species | Human |
| A.A. Sequence | Glu1291 - Gln1550 |
| Expression System | E. coli |
| Alternate Names | Chromodomain-helicase-DNA-binding protein 4; Mi-2b; EC 3.6.4.12; Mi-2 autoantigen 218 kDa protein; CHD-4; Mi2-beta; ATP-dependent helicase CHD4; Mi2-BETA |
Properties
| Form | Powder |
|---|---|
| Buffer | PBS |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration approximately 1 mg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C, protected from light and moisture, for up to 12 months. After reconstitution , aliquot and store at 2 to 8°C for up to 2 days, or at -20°C or -80°C for up to 3 months Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
Bioinformation
| Gene Symbol | CHD4 |
|---|---|
| Gene Full Name | chromodomain helicase DNA binding protein 4 |
| Background | The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] |
| Function | Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. [UniProt] |
