ARG70702
Human Endotrophin recombinant protein (His-tagged, C-ter)
Human Endotrophin recombinant protein (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged (C-ter) Human Endotrophin recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | Endotrophin |
| Species | Human |
| A.A. Sequence | Thr3101 - Thr3177 |
| Expression System | CHO |
| Alternate Names | COL6A3; Collagen Type VI Alpha 3 Chain; BTHLM1C; Collagen Alpha-3(VI) Chain; BTHLM1; Collagen, Type VI, Alpha 3; UCMD1C; Epididymis Secretory Sperm Binding Protein; DYT27; Collagen VI, Alpha-3 Polypeptide; UCMD1 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | COL6A3 |
|---|---|
| Gene Full Name | Collagen Type VI Alpha 3 Chain |
| Background | This gene encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described. [provided by RefSeq, Jun 2009] |
| Function | Collagen VI acts as a cell-binding protein. [UniProt] |
| Cellular Localization | Extracellular matrix; Secreted. [UniProt] |
| PTM | Disulfide bond; Glycoprotein; Hydroxylation; Phosphoprotein. [UniProt] |
