ARG70732
Human Guanylate Cyclase C recombinant protein (His-tagged, C-ter)
Human Guanylate Cyclase C recombinant protein (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged (C-ter) Human Guanylate Cyclase C recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | Guanylate Cyclase C |
| Species | Human |
| A.A. Sequence | Ser24 - Gln430 |
| Expression System | CHO |
| Alternate Names | MECIL; STAR; STA receptor; MUCIL; hSTAR; Heat-stable enterotoxin receptor; Intestinal guanylate cyclase; Guanylyl cyclase C; GUC2C; EC 4.6.1.2; DIAR6; GC-C |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | Gucy2c |
|---|---|
| Gene Full Name | guanylate cyclase 2C |
| Function | Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin. [UniProt] |
| PTM | Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation. |
