ARG70761
Human IL2 recombinant protein (Active) (His-tagged, C-ter)
Human IL2 recombinant protein (Active) (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged (C-ter) Active Human IL2 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | IL2 |
| Species | Human |
| A.A. Sequence | Ala21 - Gln169 |
| Expression System | CHO |
| Activity | Active |
| Activity Note | Determined by its ability to induce proliferation in CTLL-2 cells. The ED₅₀ for this effect is less than 15 ng/mL. |
| Alternate Names | TCGF; IL-2; lymphokine; Interleukin-2; Aldesleukin; T-cell growth factor |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IL2 |
|---|---|
| Gene Full Name | interleukin 2 |
| Background | Interleukin 2 (IL-2) is the cytokine secreted by T-cells immediately after the T cell receptors are activated by the binding of foreign antigens. The cytokine stimulates the growth, proliferation and differentiation of naïve T-cells into “effecter T-cells”, promotes the survival of antigen specific “memory T-cell”, and stimulates the maturation of “regulatory T-cells”. The cytokine is crucial for the development of adapted immunity, immune memory and the modulation of auto-immunity. |
| Function | Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. [UniProt] |
