ARG70691
Human IL21 recombinant protein (His-tagged, C-ter)
Human IL21 recombinant protein (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged (C-ter) Human IL21 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | IL21 |
| Species | Human |
| A.A. Sequence | Pro25 - Ser146 |
| Expression System | CHO |
| Alternate Names | Za11; IL-21; CVID11; Interleukin-21 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IL21 |
|---|---|
| Gene Full Name | interleukin 21 |
| Background | IL-21 is a homodimeric, non-glycosylated polypeptide containing 133 amino acid residues and has a molecular weight of 15.5 kDa. IL-21 is a cytokine produced by activated T-cells and can elicit the proliferation of T and B cells and natural killer cells (NK). From recent research, IL-21 has the potential to serve as a target for immunotherapy treatment for treating diseases. |
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. [UniProt] |
