ARG70623
Human MIP4 recombinant protein (Active)
Human MIP4 recombinant protein (Active) for SDS-PAGE
Overview
| Product Description | E. coli expressed, Active Human MIP4 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | MIP4 |
| Species | Human |
| A.A. Sequence | Ala21 - Ala89 |
| Expression System | E. coli |
| Activity | Active |
| Activity Note | Determined by a chemotaxis bioassay using human T- lymphocytes is in a concentration of 1.0 - 10 ng/ml. |
| Alternate Names | Small-inducible cytokine A18; 3-69; PARC; Alternative macrophage activation-associated CC chemokine 1; Macrophage inflammatory protein 4; SCYA18; Dendritic cell chemokine 1; CC chemokine PARC; 4-69; 1-68; C-C motif chemokine 18; DC-CK1; AMAC1; Pulmonary and activation-regulated chemokine; AMAC-1; DCCK1; MIP-4; CKb7 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 96% (by SDS-PAGE or HPLC). |
| Buffer | PBS(pH 7.0) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CCL18 |
|---|---|
| Gene Full Name | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
| Background | This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014] |
| Function | Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. [UniProt] |
| PTM | The Cys-30/Cys-54 disulfide bond is required for activity. |
