ARG70814
Human ROR1 recombinant protein (Active) (His-tagged, C-ter)
Human ROR1 recombinant protein (Active) (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged (C-ter) Active Human ROR1 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | ROR1 |
| Species | Human |
| A.A. Sequence | Gln30 - Glu403 |
| Expression System | CHO |
| Activity | Active |
| Activity Note | Determinedd by its ability to bind mouse ROR1 Antibody in functional ELISA. Immobilized Recombinant mouse ROR1 Protein can bind mouse ROR1 Antibody. |
| Alternate Names | Tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; EC 2.7.10.1; NTRKR1; dJ537F10.1 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | ROR1 |
|---|---|
| Gene Full Name | receptor tyrosine kinase-like orphan receptor 1 |
| Background | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] |
| Function | Tyrosine-protein kinase receptor whose role is not yet clear. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
