ARG70888
Human TLS / FUS recombinant protein (mSUMO-tagged, N-ter / His-tagged, C-ter)
Human TLS / FUS recombinant protein (mSUMO-tagged, N-ter / His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | E. coli expressed, Human mSUMO-tagged (N-ter) / His-tagged (C-ter) TLS / FUS recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | TLS / FUS |
| Species | Human |
| A.A. Sequence | Gly231 - Gly390 |
| Expression System | E. coli |
| Alternate Names | TLS; RNA-binding protein FUS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein |
Properties
| Form | Powder |
|---|---|
| Buffer | PBS |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration approximately 1 mg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C, protected from light and moisture, for up to 12 months. After reconstitution , aliquot and store at 2 to 8°C for up to 2 days, or at -20°C or -80°C for up to 3 months Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
Bioinformation
| Gene Symbol | FUS |
|---|---|
| Gene Full Name | FUS RNA binding protein |
| Background | This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] |
| Function | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| PTM | Isopeptide bond; Methylation; Phosphoprotein; Ubl conjugation. [UniProt] |
