ARG70715
Human TNFRSF18 recombinant protein (Active) (His-tagged, C-ter)
Human TNFRSF18 recombinant protein (Active) (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged (C-ter) Active Human TNFRSF18 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | TNFRSF18 |
| Species | Human |
| A.A. Sequence | Gln26 - Glu161 |
| Expression System | CHO |
| Activity | Active |
| Activity Note | Determinedd by its ability to bind human AITRL in functional ELISA. Immobilized Recombinant human AITRL Protein at 2 μg/mL (100 μL/well) can bind Recombinant Human GITR Protein. |
| Alternate Names | AITR; CD antigen CD357; Tumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; Gitr |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 90% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | Tnfrsf18 |
|---|---|
| Gene Full Name | tumor necrosis factor receptor superfamily, member 18 |
| Background | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
| Function | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity). [UniProt] |
| Cellular Localization | Secreted, cell surface |
