ARG70680
Human TNFSF11 recombinant protein (Active) (His-tagged, C-ter)
Human TNFSF11 recombinant protein (Active) (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged (C-ter) Active Human TNFSF11 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | TNFSF11 |
| Species | Human |
| A.A. Sequence | Lys158 - Asp316 |
| Expression System | CHO |
| Activity | Active |
| Activity Note | Determinedd by its ability to bind mouse RANKL Antibody in functional ELISA. Immobilized Recombinant mouse RANKL Protein can bind mouse RANKL Antibody. |
| Alternate Names | TRANCE; Osteoprotegerin ligand; CD254; sOdf; Receptor activator of nuclear factor kappa-B ligand; OPTB2; RANKL; OPGL; Tumor necrosis factor ligand superfamily member 11; hRANKL2; TNF-related activation-induced cytokine; Osteoclast differentiation factor; ODF; CD antigen CD254 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | Tnfsf11 |
|---|---|
| Gene Full Name | tumor necrosis factor (ligand) superfamily, member 11 |
| Background | RANK (receptor activator of NF-kB) is a member of the TNFR family, identified as a dendritic cell membrane protein. Murine sRANK Ligand is a soluble 19.4 kDa protein, comprising the TNF-like extracellular domain of RANKL (174 amino acids). The full length of RANK Ligand is 39.6 kDa containing 36 amino acids. |
| Function | Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [UniProt] |
