ARG70609
Mouse Eotaxin recombinant protein (Active)
Mouse Eotaxin recombinant protein (Active) for SDS-PAGE
Overview
| Product Description | E. coli expressed, Active Mouse Eotaxin recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | Eotaxin |
| Species | Mouse |
| A.A. Sequence | His24 - Pro97 |
| Expression System | E. coli |
| Activity | Active |
| Activity Note | Determined by a chemotaxis bioassay using purified eosinophils is in a concentration range of 100 - 1000 ng/ml. |
| Alternate Names | CCL11; C-C Motif Chemokine Ligand 11; Eotaxin; SCYA11; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin); Chemokine (C-C Motif) Ligand 11; Eosinophil Chemotactic Protein; Eotaxin-1; MGC22554; Small-Inducible Cytokine A11; C-C Motif Chemokine 11 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 97% (by SDS-PAGE or HPLC). |
| Buffer | 20 mM PB, with 150 mM NaCl (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CCL11 |
|---|---|
| Gene Full Name | C-C Motif Chemokine Ligand 11 |
| Background | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014] |
| Function | Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| PTM | Disulfide bond; Glycoprotein. [UniProt] |
