ARG30214

Phospho STAT5A Antibody Duo (Total, pY694)

Gene Regulation antibody; Signaling Transduction antibody
publication_link Publication2

Component

Cat No Component Name Host clonality Reactivity Application Package
ARG51552 anti-STAT5A phospho (Tyr694) antibody Rabbit pAb Hu, Ms, Rat WB, IHC-P 50 μl
ARG65593 anti-STAT5A antibody Rabbit pAb Hu IHC-P, WB 50 μl

Overview

Product Description STAT5A belongs to STAT family of transcription factors which can be activated by various stimuli such as cytokines and growth factors, including IL-2, GM-CSF, Erythropoietin and Thrombopoietin. The phosphorylation of STAT5A at Tyr694 residue by SRS Kinase upon Erythropoietin stimulation triggers its activation and is responsible for EPO-induced signal transduction. STAT5A phosphorylation can also be induced by Prolactin to increase its DNA binding and transcription ability. Lin and Leonard. 2000. Oncogene 19(21):2566 Okutani et al. 2001. Oncogene 20(45):6643 Gouilleux et al. 1994. EMBO J 13(18):4361-9
Target Name STAT5A
Alternate Names Phospho STAT5A antibody; Phospho Signal transducer and activator of transcription 5A antibody; STAT5A phospho (Tyr694) antibody; STAT5A antibody

Properties

Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Full Name Phospho Signal transducer and activator of transcription 5A (STAT5A) Antibody Duo (Total, pY694)
Research Area Gene Regulation antibody; Signaling Transduction antibody

Images (4) Click the Picture to Zoom In

  • ARG51552 anti-STAT5A phospho (Tyr694) antibody WB image

    Western Blot: extracts from K562 cells untreated or treated with G-CSF stained with anti-STAT5A (phospho Tyr694) antibody ARG51552.

  • ARG51552 anti-STAT5A phospho (Tyr694) antibody IHC-P image

    Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-STAT5A (phospho Tyr694) antibody ARG51552 (left) or the same antibody preincubated with blocking peptide (right).

  • ARG65593 anti-STAT5A Antibody IHC-P image

    Immunohistochemistry: paraffin-embedded Human breast carcinoma tissue stained with ARG65593 (STAT5A Antibody) at 1/50 dilution, or the same antibody preincubated with synthetic peptide (right). (Original magnification: ×200)

  • ARG65593 anti-STAT5A Antibody WB image

    Western Blot: ARG65593 STAT5A Antibody at 1/500 dilution with 30 μg of lysates.
    (1) HeLa cell
    (2) K562 cell

    Exposure time: 1 minute.

Specific References

Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.

ARG51552: WB / Rat

Zhang Yuezhu et al.
Environ Sci Pollut Res Int.,  (2019)

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Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.

ARG51552: WB / Rat

Zhang Yuezhu et al.
Ecotoxicol Environ Saf.,  (2019)

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