ARG70627
Rat CXCL10 / IP-10 recombinant protein (Active)
Rat CXCL10 / IP-10 recombinant protein (Active) for SDS-PAGE
Overview
| Product Description | E. coli expressed, Active Rat CXCL10 / IP-10 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CXCL10 / IP-10 |
| Species | Rat |
| A.A. Sequence | Ile22 - Pro98 |
| Expression System | E. coli |
| Activity | Active |
| Activity Note | Determined by a chemotaxis bioassay using human CXCR3 transfected HEK293 cells is in a concentration range of 10 - 50 ng/ml. |
| Alternate Names | CXCL10; C-X-C Motif Chemokine Ligand 10; IP-10; GIP-10; SCYB10; IFI10; Crg-2; Mob-1; INP10; C7; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10; 10 KDa Interferon Gamma-Induced Protein; Small-Inducible Cytokine B10; C-X-C Motif Chemokine 10; Protein 10 From Interferon (Gamma)-Induced Cell Line; Interferon-Inducible Cytokine IP-10; Chemokine (C-X-C Motif) Ligand 10; Gamma IP10; Gamma-IP10 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 96% (by SDS-PAGE or HPLC). |
| Buffer | 20 mM PB, with 150 mM NaCl (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CXCL10 |
|---|---|
| Gene Full Name | C-X-C Motif Chemokine Ligand 10 |
| Background | This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020] |
| Function | Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| PTM | Citrullination; Disulfide bond. [UniProt] |
