ARG45971
anti-ABCA7 antibody
anti-ABCA7 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ABCA7 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ABCA7 |
| Antigen Species | Human |
| Immunogen | A 18 amino acid synthetic peptide within aa. 130 - 180 of human ABCA7. |
| Conjugation | Un-conjugated |
| Alternate Names | ABCA7; Autoantigen SS-N; ABCX; ATP-binding cassette sub-family A member 7; ABCA-SSN; Macrophage ABC transporter |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 240 kDa |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8IZY2 Human ATP-binding cassette sub-family A member 7 |
|---|---|
| Gene Symbol | ABCA7 |
| Gene Full Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
| Background | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008] |
| Function | Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. [UniProt] |
| Calculated MW | 236 kDa |
Images (3) Click the Picture to Zoom In
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ARG45971 anti-ABCA7 antibody IHC-P image
Immunohistochemistry: Human spleen stained with ARG45971 anti-ABCA7 antibody.
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ARG45971 anti-ABCA7 antibody ICC/IF image
Immunofluorescence: 293 stained with ARG45971 anti-ABCA7 antibody.
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ARG45971 anti-ABCA7 antibody WB image
Western blot: 293 stained with ARG45971 anti-ABCA7 antibody.
