anti-ACE2 antibody

anti-ACE2 antibody for ELISA,ICC/IF,Immunohistochemistry,Western blot and Human

Cell Biology and Cellular Response antibody


Product Description Rabbit Polyclonal antibody recognizes ACE2
Tested Reactivity Hu
Tested Application ELISA, ICC/IF, IHC, WB
Specificity Anti-ACE2 has no cross response to ACE1.
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ACE2
Antigen Species Human
Immunogen Synthetic peptide within the first 50 aa of Human ACE2.
Conjugation Un-conjugated
Alternate Names Angiotensin-converting enzyme homolog; ACEH; Angiotensin-converting enzyme 2; Metalloprotease MPROT15; ACE-related carboxypeptidase; EC

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF10 μg/ml
IHC2 μg/ml
WB1 μg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Human Kidney Tissue Lysate
Observed Size ~ 105 kDa


Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 59272 Human ACE2

Swiss-port # Q9BYF1 Human Angiotensin-converting enzyme 2

Gene Symbol ACE2
Gene Full Name angiotensin I converting enzyme 2
Background ACE2 Antibody: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Function Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. [UniProt]
Highlight Related products:
ACE2 antibodies; ACE2 ELISA Kits; ACE2 recombinant proteins; Anti-Rabbit IgG secondary antibodies;
Related news:
HMGB1, a biomarker and therapeutic target in COVID-19
ACE2, receptor of 2019-nCoV
Research Area Cell Biology and Cellular Response antibody
Calculated MW 92 kDa
PTM N-glycosylation on Asn-90 may limit SARS infectivity.
Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.

Images (3) Click the Picture to Zoom In

  • ARG54914 anti-ACE2 antibody WB image

    Western blot: human kidney lysate stained with ARG54914 anti-ACE2 antibody at 1 ug/ml dilution.

  • ARG54914 anti-ACE2 antibody IHC image

    Immunohistochemistry: human kidney cells stained with ARG54914 anti-ACE2 antibody at 2 ug/ml dilution.

  • ARG54914 anti-ACE2 antibody ICC/IF image

    Immunofluorescence: Human Kidney cells stained with ARG54914 anti-ACE2 antibody at 10 ug/ml dilution.