ARG45127
anti-ADA antibody
anti-ADA antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ADA |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ADA |
| Antigen Species | Mouse |
| Immunogen | Recombinant protein containing to mouse ADA. |
| Conjugation | Un-conjugated |
| Alternate Names | ADA; adenosine deaminase; Adenosine deaminase; EC 3.5.4.4; Adenosine aminohydrolase |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 45 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.01% Sodium azide and 4% Trehalose. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | ADA |
|---|---|
| Gene Full Name | adenosine deaminase |
| Background | This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008] |
| Function | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. [UniProt] |
| Cellular Localization | Cell membrane; Cell junction; Cytoplasmic vesicle lumen; Cytoplasm; Lysosome [UniProt] |
| Calculated MW | 40 kDa |
| PTM | Acetylation. [UniProt] |
Images (4) Click the Picture to Zoom In
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ARG45127 anti-ADA antibody IHC-P image
Immunohistochemistry: Rat small intestine stained with ARG45127 anti-ADA antibody at 1 μg/ml dilution.
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ARG45127 anti-ADA antibody WB image
Western blot: Rat stomach and rat kidney stained with ARG45127 anti-ADA antibody at 0.5 μg/ml dilution.
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ARG45127 anti-ADA antibody IHC-P image
Immunohistochemistry: Mouse spleen stained with ARG45127 anti-ADA antibody at 1 μg/ml dilution.
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ARG45127 anti-ADA antibody WB image
Western blot: Mouse small intestine stained with ARG45127 anti-ADA antibody at 0.5 μg/ml dilution.
