ARG10581

anti-AMACR / p504S antibody [Q17-L]

anti-AMACR / p504S antibody [Q17-L] for IHC-Formalin-fixed paraffin-embedded sections and Human

Overview

Product Description Rabbit Monoclonal antibody [Q17-L] recognizes AMACR / p504S
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone Q17-L
Isotype IgG
Target Name AMACR / p504S
Antigen Species Human
Immunogen Synthetic peptide around the N-terminus of Human P504S
Conjugation Un-conjugated
Full Name alpha-methylacyl-CoA racemase
Alternate Names CBAS4; RACE; RM; EC 5.1.99.4; Alpha-methylacyl-CoA racemase; AMACRD; 2-methylacyl-CoA racemase

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer 20 mM Tris-HCl (pH 8.0), 0.05% Sodium azide and 20 mg/ml BSA
Preservative 0.05% Sodium azide
Stabilizer 20 mg/ml BSA
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 23600 Human AMACR

Swiss-port # Q9UHK6 Human Alpha-methylacyl-CoA racemase

Gene Symbol AMACR
Gene Full Name alpha-methylacyl-CoA racemase
Background This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Function Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. [UniProt]

Images (2) Click the Picture to Zoom In

  • ARG10581 anti-AMACR / p504S antibody [Q17-L] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human papillary renal cell carcinoma (4 µm sections) stained with ARG10581 anti-AMACR / p504S antibody [Q17-L].

  • ARG10581 anti-AMACR / p504S antibody [Q17-L] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human prostate adenocarcinoma (4 µm sections) stained with ARG10581 anti-AMACR / p504S antibody [Q17-L].