anti-AMOTL2 antibody

anti-AMOTL2 antibody for Western blot and Human,Mouse

Cell Biology and Cellular Response antibody


Product Description Rabbit Polyclonal antibody recognizes AMOTL2
Tested Reactivity Hu, Ms
Predict Reactivity Bov, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name AMOTL2
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 126-152 (Center) of Human AMOTL2.
Conjugation Un-conjugated
Alternate Names Leman coiled-coil protein; Angiomotin-like protein 2; LCCP

Application Instructions

Application Suggestion
Tested Application Dilution
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse liver


Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 51421 Human AMOTL2

GeneID: 56332 Mouse AMOTL2

Swiss-port # Q8K371 Mouse Angiomotin-like protein 2

Swiss-port # Q9Y2J4 Human Angiomotin-like protein 2

Gene Symbol AMOTL2
Gene Full Name angiomotin like 2
Background Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Function Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. [UniProt]
Cellular Localization Recycling endosome.
Research Area Cell Biology and Cellular Response antibody
Calculated MW 86 kDa
PTM Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway.

Images (1) Click the Picture to Zoom In

  • ARG54809 anti-AMOTL2 antibody WB image

    Western blot: 35 µg of Mouse liver lysate stained with ARG54809 anti-AMOTL2 antibody.