ARG46009
anti-APH1A antibody
anti-APH1A antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes APH1A |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | APH1A |
| Antigen Species | Human |
| Immunogen | A 18 amino acid synthetic peptide within aa. 80 - 130 of human APH1A. |
| Conjugation | Un-conjugated |
| Alternate Names | APH1A; APH-1A; APH-1a; 6530402N02Rik; APH-1; CGI-78; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor; Aph-1alpha |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 28 kDa |
Properties
| Purification | Affinity chromatography purified |
|---|---|
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | APH1A |
| Gene Full Name | Aph-1 Homolog A, Gamma-Secretase Subunit |
| Background | This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011] |
| Calculated MW | 29 kDa |
Images (2) Click the Picture to Zoom In
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ARG46009 anti-APH1A antibody IHC-P image
Immunohistochemistry: Human brain stained with ARG46009 anti-APH1A antibody.
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ARG46009 anti-APH1A antibody WB image
Western blot: RAW264.7 stained with ARG46009 anti-APH1A antibody.
