ARG45554
anti-ARS2 antibody
anti-ARS2 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ARS2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ARS2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human ARS2. |
| Conjugation | Un-conjugated |
| Alternate Names | SRRT; Serrate, RNA Effector Molecule; ARS2; Serrate; Asr2; Serrate RNA Effector Molecule Homolog; Arsenite-Resistance Protein 2; Arsenite Resistance Protein; Serrate RNA Effector Molecule Homolog (Arabidopsis); Arsenate Resistance Protein ARS2; Arsenate Resistance Protein 2; ASR2 |
Application Instructions
| Application Suggestion |
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| Observed Size | 125 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q99MR6 Mouse Serrate RNA effector molecule homolog Swiss-port # Q9BXP5 Human Serrate RNA effector molecule homolog |
|---|---|
| Gene Symbol | SRRT |
| Gene Full Name | Serrate, RNA Effector Molecule |
| Background | Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in primary miRNA processing. Located in nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Feb 2025] |
| Function | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 101 kDa |
| PTM | Acetylation; Isopeptide bond; Methylation; Phosphoprotein; Ubl conjugation. [UniProt] |
Images (9) Click the Picture to Zoom In
-
ARG45554 anti-ARS2 antibody IHC-P image
Immunohistochemistry: Human endometrioid adenocarcinoma stained with ARG45554 anti-ARS2 antibody at 2 μg/ml dilution.
-
ARG45554 anti-ARS2 antibody ICC/IF image
Immunofluorescence: A549 stained with ARG45554 anti-ARS2 antibody at 5 μg/ml dilution.
-
ARG45554 anti-ARS2 antibody WB image
Western blot: MCF-7 stained with ARG45554 anti-ARS2 antibody at 0.5 μg/ml dilution.
-
ARG45554 anti-ARS2 antibody IP image
Immunoprecipitation: MCF-7 lysate immunoprecipitated with 2 μg ARG45554 anti-ARS2 antibody.
-
ARG45554 anti-ARS2 antibody FACS image
Flow Cytometry: MCF-7 stained with ARG45554 anti-ARS2 antibody at 1 µg/10^6 cells dilution.
-
ARG45554 anti-ARS2 antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG45554 anti-ARS2 antibody at 2 μg/ml dilution.
-
ARG45554 anti-ARS2 antibody WB image
Western blot: Rat brain stained with ARG45554 anti-ARS2 antibody at 0.5 μg/ml dilution.
-
ARG45554 anti-ARS2 antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG45554 anti-ARS2 antibody at 2 μg/ml dilution.
-
ARG45554 anti-ARS2 antibody WB image
Western blot: Mouse brain stained with ARG45554 anti-ARS2 antibody at 0.5 μg/ml dilution.
