ARG54433

anti-ARTS antibody

anti-ARTS antibody for Immunohistochemistry,Western blot and Human

Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody

Overview

Product Description

Rabbit Polyclonal antibody recognizes ARTS

Tested Reactivity Hu
Tested Application IHC, WB
Specificity This antibody recognizes human ARTS (Apoptosis Related Protein in TGF- Signaling Pathway), a novel mito-chondrial septin-like protein. ARTS translocates to the cell nucleus when apoptosis occurs. It enhances apoptosis induced by TGF- and other inducers of apoptosis, such as TNF- and Fas ligand.
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ARTS
Antigen Species Human
Immunogen Synthetic peptide around aa. 3-14 of Human ARTS.
Conjugation Un-conjugated
Alternate Names Apoptosis-related protein in the TGF-beta signaling pathway; PNUTL2; ARTS; Peanut-like protein 2; Cell division control-related protein 2; CE5B3; Brain protein H5; CE5B3 beta; Septin-4; BRADEION; H5; MART; Bradeion beta; hucep-7; hCDCREL-2; SEP4; Cerebral protein 7

Application Instructions

Application Suggestion
Tested Application Dilution
IHCAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Human lung, kidney and spleen

Properties

Form Liquid
Purification Immunoaffinity chroma-tography
Buffer PBS (pH 7.4) and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 5631 Human PRPS1

Swiss-port # P60891 Human Ribose-phosphate pyrophosphokinase 1

Gene Symbol SEPT4
Gene Full Name septin 4
Background This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]
Function Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. [UniProt]
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody
Calculated MW 55 kDa

Images (2) Click the Picture to Zoom In

  • ARG54433 anti-ARTS antibody WB image

    Western Blot: 1:human lung; 2:spleen; 3:kidney stained with ARG54433 anti-ARTS antibody at 2 μg/ml dilution.

  • ARG54433 anti-ARTS antibody IHC image

    Immunohistochemistry: human lung tissue stained with ARG54433 anti-ARTS antibody at 2 μg/ml dilution.